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Kazuki Nagashima (he, him)

Kazuki Nagashima (he, him)

Kazuki Nagashima (he, him)


Kazuki Nagashima (永島 一樹) grew up in Tokyo, Japan. His childhood experience with food allergies drove his interest in the gut immune system and motivated him to go to medical school at the University of Tokyo, where he was inspired by a Clostridium difficile infection caused by dysbiosis of the microbiota.  He was fascinated by the mysterious intestinal ecosystem in which the immune system permits diet and microbiome and eliminates pathogens.

To learn state-of-art immunology, he started his Ph.D. training in Dr. Hiroshi Takayanagi’s lab at the University of Tokyo. He addressed a longstanding question in the host-microbe interaction – how antigens of the microbiome are recognized by the host's immune system and initiate an IgA response. He discovered a previously uncharacterized mesenchymal cell subset that induces epithelial microfold (M) cells and promotes the antigen-specific IgA response.

To explore the host-microbiome interaction from a microbial perspective, he joined Michael Fischbach Lab at Stanford University as a postdoc. He developed a technology to understand the “physiological” gut ecosystem at high resolution. He colonized germ-free mice with a complex defined gut community (>100 strains) and profiled T cell responses to each strain individually. His work provides a framework to logically design microbiome therapeutics for systemic disorders.


Kazuki Nagashima (he, him)

Senior Research Scientist

of Michael Fischbach Lab

at Stanford University

Education & Experience

Funding & Award

2022 - Present
Senior Research Scientist
Michael Fischbach Lab, Stanford University

NIAID K99/R00 Pathway to Independence Award

2017 - 2022
Postdoctoral Scholar
Michael Fischbach Lab, Stanford University

Human Frontier Science Program Long-Term Fellowships
Astellas Foundation Fellowships for Research on Metabolic Disorders
Kanae Fundation for the Promotion of Medical Science

2013 - 2017
Hiroshi Takayanagi Lab
The University of Tokyo, Japan

Nature Immunology Young Investigator Award

Kibou Scholarships for a Doctoral Student in Immunology

Young Investigator Award, Osteoimmunology Conference

Graduate Program for Leaders in Life Innovation

2007 - 2013
The University of Tokyo, Japan

Otsubo Osamu Fellowship for a Medical student


My research has been supported by wonderful mentors and collaborators, including the members of Michael A. Fischbach Lab, Hiroshi Takayanagi Lab, Mark Davis Lab, and Elizabeth Sattely Lab.
This website was helped by Jamie E. Blum and Victor K. Yu.
The image of a macrophage is from the National Cancer Institute, one of bacteria is from CDC, and one of diversity/inclusion is from Clay Banks.


Email: kazuki.nagashima[at]

Link to Twitter account: 

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