Blum JE*, Kong R, Schulman EA, Chen FM, Upadhyay R, Romero-Meza G, Littman DR, Fischbach MA, Nagashima K*, Sattely ES*.

Identification and characterization of dietary antigens in oral tolerance. 
Science Immunology. 2026, 11 (117). https://doi.org/10.1126/sciimmunol.aeb4684.
*Corresponding authors

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Nagashima K*.
Blockbuster T cells in the gut: A high-resolution view of immune modulation by the gut microbiome is presented 
Science. 2024. Vol 385, Issue 6704. pp. 36-37. DOI: 10.1126/science.adq2335
*Corresponding author

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Nagashima K, Zhao A, Atabakhsh K, Bae M, Blum JE, Weakley A, Jain S, Meng X, Cheng AG, Wang M, Higginbottom S, Dimas A, Murugkar P, Sattely ES, Moon JJ, Balskus EP, Fischbach MA.
Mapping the T Cell Repertoire to a Complex Gut Bacterial Community
Nature. 2023. doi: 10.1038/s41586-023-06431-8.

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Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA. 
Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome. 
Cell. 2023 Jun 22;186(13):2839-2852.e21. doi: 10.1016/j.cell.2023.05.037. PubMed PMID: 37352836; PubMed Central PMCID: PMC10299816.

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Chen YE, Bousbaine D, Veinbachs A, Atabakhsh K, Dimas A, Yu VK, Zhao A, Enright NJ, Nagashima K, Belkaid Y, Fischbach MA. 
Engineered skin bacteria induce antitumor T cell responses against melanoma. 
Science. 2023 Apr 14;380(6641):203-210. doi: 10.1126/science.abp9563. Epub 2023 Apr 13. PubMed PMID: 37053311.

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Cheng AG, Ho PY, Aranda-Díaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA. 
Design, construction, and in vivo augmentation of a complex gut microbiome. 
Cell. 2022 Sep 15;185(19):3617-3636.e19. doi: 10.1016/j.cell.2022.08.003. Epub 2022 Sep 6. PubMed PMID: 36070752; PubMed Central PMCID: PMC9691261.

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Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. 
Depletion of microbiome-derived molecules in the host using Clostridium genetics. 
Science. 2019 Dec 13;366(6471). doi: 10.1126/science.aav1282. PubMed PMID: 31831639; PubMed Central PMCID: PMC7141153.

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Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, Iwakura Y, Nakashima T, Okamoto K, Takayanagi H. 
Host defense against oral microbiota by bone-damaging T cells. 
Nature Communications. 2018 Feb 16;9(1):701. doi: 10.1038/s41467-018-03147-6. PubMed PMID: 29453398; PubMed Central PMCID: PMC5816021.

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Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, Nakashima T, Takayanagi H. 
Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. 
Biochem Biophys Res Commun. 2017 Nov 4;493(1):437-443. doi: 10.1016/j.bbrc.2017.09.004. Epub 2017 Sep 5. PubMed PMID: 28882590.

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Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H.

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. 
Nature Immunology. 2017 Jun;18(6):675-682. doi: 10.1038/ni.3732. Epub 2017 Apr 24. PubMed PMID: 28436956.

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